Tao Yi et al developed a new solid self-microemulsifying drug delivery system SMEDDS for oral poorly water-soluble drugs such as nimodipine and to evaluate its oral bioavailability in healthy rabbits. Tacrolimus FK , a member macrolide lactone isolated from Streptomyces tsukubaensi is a potent immunosuppressant and has been clinically used for preventing rejection of liver, heart, kidney, pancreas, lung and bone marrow after transplantation 1 — 3. After 30 minutes, samples were filtered through 0. The dissolution medium was ml of HCl 0. Phase behavior and microstructure.

University of Mumbai, India, Construction of Ternary Phase Diagram: Statistically significant difference was obtained for both i. As ratio of surfactant to cosurfactant is constant, study clearly distinguished ability of cosurfactants to improve emulsification of surfactants. Drug and excipients Sr. Where d max and d min are maximum and minimum ferret diameters of pellets, Ferret diameter is the distance between two tangents on opposite sides of the particle parallel to some fixed direction; so, based on direction several Ferret diameters can be determined for the particle.

solid smedds thesis

However it is reported that increasing the amount of SEDDS of the pellets or granules would weaken the interaction within the pellets due to incomplete adsorption on pellets components and decrease their hardness.

This study was a Pharm.

Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

These advantages of FK coupled skedds its long-term tolerability led to improved graft and patient survival indicating its clinical potential 3. Oily phase was added to this mixture in 1: Open in a separate window.

Hence, surfactant to cosurfactant ratio was maintained at 2: Mean Droplet size nm. Conclusion The overall results of this study indicated that an improved formulation of loratadin SNEDDS pellets was successfully developed using the extrusion-spheronization technique.


Design and Evaluation of Self-Microemulsifying Drug Delivery System (SMEDDS) of Tacrolimus

Statistical analysis The effects of independent variables on the experimental response were modeled using a second order polynomial equation with a backward, stepwise linear regression technique. The effects of independent variables on the experimental smedfs were modeled using a second order polynomial equation with a backward, stepwise linear regression technique. Adv Drug Deliver Rev. The results of in vitro dissolution revealed that the pelletization process of loratadin SNEDDS not only had no inappropriate effect on its self-emulsification properties, but also improve the drug release rate from resulted nano-emulsions.

Equilibrium solubility of FK in various excipients and buffers was determined by shake flask method. In this study, we intended to prepare and characterize solid self-nanoemulsifying drug delivery system for oral delivery of loratadin as the model insoluble drug. Preparation and characterization of a self-emulsifying pellet formulation. Rationale behind the study: D thesis of Ms.

Ratio of oil to surfactant was decided on the basis of requirements stated by Pouton 13 for spontaneously emulsifying systems and represents Type III system. FK was a gift from Glenmark Pharmaceuticals Ltd.

Formulation formed transparent, gel like intermediate structure prior to dispersing completely but could form microemulsion. Hosmani Professor in Pharmaceutics Govt.

solid smedds thesis

The thhesis ingredients include lactose, hydroxypropyl methylcellulose, croscarmellose sodium and magnesium stearate. To some extent, this combination offers the sum of the benefits of both SEDDS and solid dosage forms.


Hosmani Professor in Pharmaceutics Co-guided by: Additionally, FK shows large intra- and inter-individual pharmacokinetic variability 3. In addition, microemulsion formed was sufficiently stable and had very small globule size which provides a large interfacial surface area for drug diffusion. Carbitol and propylene glycol, hydrophilic cosurfactants increased spontaneity of microemulsion formation. Thwsis review Bok Ki Kang et al developed self-microemulsifying drug delivery system SMEDDS for oral bioavailability enhancement of a poorly water soluble drug, simvastatin.

Recently the solic nanoemulsifying drug delivery systems SNEDDS have shown dramatic effects on improving oral bioavailability of poorly soluble drugs. Cosurfactant S mix 1 1: Tacrolimus in solid organ transplantation: Three independent variables, including the percentage of Aerosil three levelsthe Crosscarmellose three levelsand the amount of liquid SNEDDS two levels were used Table 1.

For the sphericity a value of unity considers a perfect spheroid and smaller values show the deviation from spherical form.


Cremophor EL and Tween 20 rendered effective microemulsification and were selected for further study. It has been shown that finely divided solid particles can be used as emulsifying agents and emulsion stabilizer. Thus, it was thought that, combination of above factors may result in an increase in rate and extent of absorption of FK leading to its improved therapeutic efficacy over commercial formulation.

solid smedds thesis

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